The Osmodex® Drug Delivery System

OSMOLEX® ER (amantadine) contains amantadine with an immediate-release outer layer and an extended-release core that is delivered using the Osmodex Drug Delivery System.1✱ The unique pharmacokinetic profile of OSMOLEX ER delivers amantadine.1,2

How it works1

Osmotic pressure delivers amantadine at a controlled release rate

Image labeling the drug delivery of an OSMOLEX® ER (amantadine) extended-release tablet Image labeling the drug delivery of an OSMOLEX® ER (amantadine) extended-release tablet
  • Image showing that the color coating and outer layer of amantadine dissolves
    The color coating and outer layer of
    amantadine dissolve
  • Image showing that the tablet shell is semipermeable, which lets water in without letting amantadine out
    The semipermiable tablet shell allows
    water in without letting amantadine out
  • Image showing how amantadine is released through the laser-drilled hole
    Amantadine release through the laser-drilled
    hole is driven by the osmotic pressure

*The biologically inert components of the tablet remain intact during gastrointestinal transit and are eliminated
in the stool as a tablet shell.

Watch the MOA video below to learn about the Osmodex Drug Delivery System

This system utilizes an osmotic pump system to ensure a controlled and consistent release of amantadine.

References:

  1. OSMOLEX ER. Prescribing information. Vertical Pharmaceuticals, LLC; 2020.
  2. DeVries T, Dentiste A, Handiwala L, Jacobs D. Bioavailability and pharmacokinetics of once-daily amantadine extended-release tablets in healthy volunteers: results from three randomized, crossover, open-label phase 1 studies. Neurol Ther. 2019. DOI: 10.1007/s40120-019-0144-1.