The Osmodex® Drug Delivery System
OSMOLEX® ER (amantadine) contains amantadine with an immediate-release outer layer and an extended-release core that is delivered using the Osmodex Drug Delivery System.1✱ The unique pharmacokinetic profile of OSMOLEX ER delivers amantadine.1,2
How it works1
Osmotic pressure delivers amantadine at a controlled release rate
The color coating and outer layer of
The semipermiable tablet shell allows
water in without letting amantadine out
Amantadine release through the laser-drilled
hole is driven by the osmotic pressure
*The biologically inert components of the tablet remain intact during gastrointestinal transit and are eliminated
in the stool as a tablet shell.
Watch the MOA video below to learn about the Osmodex Drug Delivery System
This system utilizes an osmotic pump system to ensure a controlled and consistent release of amantadine.
- OSMOLEX ER. Prescribing information. Vertical Pharmaceuticals, LLC; 2020.
- DeVries T, Dentiste A, Handiwala L, Jacobs D. Bioavailability and pharmacokinetics of once-daily amantadine extended-release tablets in healthy volunteers: results from three randomized, crossover, open-label phase 1 studies. Neurol Ther. 2019. DOI: 10.1007/s40120-019-0144-1.