OSMOLEX® ER (amantadine) is not available in retail pharmacies. If you are prescribed OSMOLEX ER, you must be enrolled through AccessOsmolex™, a program designed to provide access and financial support.

AccessOsmolex™ Support Center logo

What is AccessOsmolex?

AccessOsmolex is a patient support services center that is focused on helping you obtain OSMOLEX ER coverage at an affordable price.

If your doctor prescribes you
OSMOLEX ER, they will need to enroll
you by sending the prescription to

Patient authorization form icon
You will have to sign a patient authorization form to complete the enrollment, but your doctor will handle the rest
AccessOsmolex™ team icon
Once you are enrolled, the AccessOsmolex team will contact you to discuss services and financial support options
AccessOsmolex™ support services icon
AccessOsmolex can provide information about a variety of payment support services, no matter what type of insurance you have
Checklist icon
Your AccessOsmolex team can help you figure out which program is right for you
AccessOsmolex™ support center icon

If you have already been prescribed OSMOLEX ER and have questions about your prescription,

call the AccessOsmolex Support Center at 1-833-OSMOLEX (1-833-676-6539).

going to cost me?1,2

OSMOLEX ER offers affordable out‑of‑pocket costs*

Average Monthly Out-of-Pocket Costs for All Medications

Specialty or Non-Preferred/Tier 4 Medicare requires patients to pay 25% to 33% coinsurance for Specialty Tier products. Non-Preferred products require a coinsurance of 24% to 50%.

Preferred/Tier 2 or 3 OSMOLEX ER expected coverage

*The Medicare threshold for drugs to qualify for placement on a specialty tier is $670 for a 1-month supply of the drug. Tier placement is ultimately based on the contract with individual insurance plans. Products with a list price (Wholesale Acquisition Cost [WAC]) over $670 are not necessarily placed on Specialty Tier for all plans. The average copayments for commercial patients are among covered workers in plans with 3 or more tiers of cost sharing for prescription drugs.

The expected tier placement of OSMOLEX ER is based on the WAC and contract negotiations with insurance plans.

Downloadable brochure icon

What do I need to know about taking OSMOLEX ER?

If you’re looking to learn more about treatment with OSMOLEX ER, download our patient brochure for more information.

What other resources are available to Parkinson’s disease patients?

There are many organizations focused on research, advocacy, care, and support for the Parkinson's disease community. These include national nonprofits, medical and research centers, government agencies, regional support groups, and advocacy groups. Each has its own special focus, but all share the common goals of improving the lives of those affected by Parkinson's disease and someday finding a cure.

Such groups provide support and information to the Parkinson’s disease community, including those who have been diagnosed with Parkinson's disease or parkinsonism, and their caregivers, families, friends, and healthcare providers.


  1. Medicare Part D: A First Look at Prescription Drug Plans in 2018. Henry J. Kaiser Family Foundation website. Published October 13, 2017. Accessed April 12, 2018.
  2. 2017 Employer Health Benefits Survey. Henry J. Kaiser Family Foundation website. Published September 19, 2017. Accessed April 12, 2018.


OSMOLEX® ER (amantadine) extended release tablets is indicated for the treatment of Parkinson’s disease and for the treatment of drug-induced extrapyramidal reactions in adult patients.



OSMOLEX ER is a prescription medicine used to treat adults with:

  • Parkinson’s disease
  • Drug-induced extrapyramidal reactions

It is not known if OSMOLEX ER is safe and effective in children.


  • have kidney problems. Do not take OSMOLEX ER if you have severe kidney problems
  • have unexpected sleepiness, take medicine to help you sleep or that makes you drowsy
  • have mental problems, such as suicidal thoughts, depression, or hallucinations
  • have unusual urges, including gambling, increased sex drive, compulsive eating, or compulsive shopping
  • drink alcoholic beverages
  • are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed. OSMOLEX ER may harm your unborn baby and can pass into your breastmilk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take sodium bicarbonate, a medicine that contains sodium bicarbonate, or are planning to receive the flu vaccine.


  • Do not drive, operate heavy machinery, or do other dangerous activities until you know how OSMOLEX ER affects you
  • You should not drink alcohol while taking OSMOLEX ER because it can increase your chances of serious side effects
  • Do not stop taking OSMOLEX ER or change your dose before talking with your doctor. Tell your doctor if you have symptoms of withdrawal such as fever, confusion, or severe muscle stiffness
  • You may receive the flu vaccine (shot or injection) but should not get the live flu vaccine (nasal spray) while taking OSMOLEX ER


OSMOLEX ER may cause serious side effects, including:

  • falling asleep during normal activities, such as driving, talking, or eating, while taking OSMOLEX ER. You may fall asleep without being drowsy or warning. The risk is greater if you take OSMOLEX ER with other medicines that cause drowsiness or drink alcohol. Tell your doctor right away if this happens
  • suicidal thoughts or actions and depression. Tell your doctor right away if you have significant changes in your mood, behaviors, or thoughts, including thoughts about hurting yourself or ending your life
  • hallucinations (seeing, or hearing things that are not real) while you are taking OSMOLEX ER or if you suddenly stop taking OSMOLEX ER
  • feeling dizzy, faint, or light-headed, especially when you stand up too quickly, when you first start OSMOLEX ER, or if your dose has been increased. Tell your doctor if you become dizzy, light-headed, or faint when standing up
  • unusual urges, including gambling, sexual, spending money, and binge eating, and the inability to control these urges. If you notice or your family notices that you are developing any unusual behaviors, talk to your doctor

The most common side effects of OSMOLEX ER include nausea, dizziness, lightheadedness, and trouble sleeping.

These are not all the possible side effects of OSMOLEX ER. Call your doctor for medical advice about side effects.You may report side effects to the FDA. Visit or call at 1-800-FDA-1088.