Because every patient is unique, OSMOLEX ER is available in multiple dose strengths.1

Image of a doctor discussing treatment with a patient Image of a doctor discussing treatment with a patient

Things to know before you start taking OSMOLEX ER:

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Take OSMOLEX ER exactly as your doctor tells you
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Start OSMOLEX ER with 1 tablet in the morning. Your doctor may change your dose if needed
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Do not stop taking OSMOLEX ER or change your dose before talking with your doctor. Tell your doctor if you have symptoms of withdrawal such as fever, confusion, or severe muscle stiffness
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OSMOLEX ER may be taken with or without food
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Swallow OSMOLEX ER tablets whole. Do not chew, crush, or divide OSMOLEX ER tablets
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If you miss a dose of OSMOLEX ER, do not make up the missed dose. Take your usual dose of OSMOLEX ER on the next day in the morning
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If you take too much OSMOLEX ER, call your doctor or go to the nearest hospital emergency room right away
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OSMOLEX ER should not be used instead of other immediate-release amantadine medicines or other extended-release amantadine medicines
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The OSMOLEX ER tablet shell does not dissolve completely even after all the drug has been released. The tablet shell may be seen in your stool


  1. OSMOLEX ER. Prescribing information. Adamas Pharmaceutical, Inc. 2021.